Skip to main content

Table 9 Protein stability change prediction results of MUpro and I-Mutant2.0 for the 33 deleterious missense mutations of epidermal and hyperproliferative keratins in mild and moderate psoriasis patients

From: Mutational analysis of epidermal and hyperproliferative type I keratins in mild and moderate psoriasis vulgaris patients: a possible role in the pathogenesis of psoriasis along with disease severity

Stages of psoriasis Gene CDS mutation AA mutation MUpro I-Mutant 2.0
SVM SVMCS NN NNCS Stability DDG
Mild K14 c.372C > A p.D124E Increase 0.05 Increase 0.71 Decrease − 0.52
c.479A > T p.K160I Decrease − 0.54 Decrease − 0.89 Decrease 0.61
c.659G > T p.G220V Increase 0.41 Increase 0.65 Decrease − 0.46
c.896G > C p.R299P Decrease − 0.57 Decrease − 0.75 Decrease − 2.22
c.944G > C p.R315P Decrease − 0.53 Decrease − 0.86 Decrease − 1.26
c.1246C > T p.R416C Decrease − 0.16 Decrease − 0.58 Decrease − 0.3
K10 c.502G > C p.E168Q Increase 0.39 Increase 0.70 Decrease − 0.01
c.679G > T p.A227S Decrease − 1 Decrease − 0.71 Decrease − 0.19
c.715G > C p.E239Q Decrease − 0.12 Decrease − 0.64 Decrease − 0.28
c.730C > G p.L244V Decrease − 1 Decrease − 0.94 Decrease − 2.03
c.770G > T p.R257M Increase 0.53 Increase 0.81 Decrease − 0.47
Moderate K14 c.388C > G p.L130V Decrease − 1 Decrease − 1 Decrease − 1.67
c.415G > C p.A139P Decrease − 0.63 Decrease − 0.88 Decrease − 1.89
c.419A > T p.N140I Decrease − 0.23 Decrease − 0.67 Increase 1.57
c.442C > T p.R148C Decrease − 1 Decrease − 1 Decrease − 0.28
c.512A > T p.D171V Decrease − 0.37 Decrease − 1 Decrease − 0.36
c.519G > T p.R173S Decrease − 1 Decrease − 1 Decrease − 2.37
c.904G > C p.A302P Increase 0.63 Increase 0.73 Decrease − 3.34
c.1057G > C p.A353P Decrease − 0.58 Decrease − 0.65 Increase − 0.65
c.1234A > T P.I412F Decrease − 1 Decrease − 0.69 Decrease − 0.95
K10 c.479A > C p.Y160S Decrease − 0.47 Decrease − 0.64 Decrease − 1.16
c.520C > A p.L174M Decrease − 1 Decrease − 1 Decrease 0.12
c.674A > C p.D225A Decrease − 0.39 Decrease − 0.78 Decrease − 0.76
c.704G > T p.R235M Decrease − 0.45 Decrease − 0.89 Decrease − 0.59
c.711G > T p.K237N Decrease − 0.60 Decrease − 1 Increase 0.26
c.785T > A p.L262Q Decrease − 1 Decrease − 1 Decrease − 1.82
K16 c.667C > G p.L223V Decrease − 1 Decrease − 1 Decrease − 1.39
K17 c.503A > T p.D168V Decrease − 0.30 Decrease − 0.60 Decrease − 0.73
c.662A > T p.N221I Decrease − 0.70 Increase 0.62 Increase 1.64
c.682G > C p.A228P Decrease − 0.04 Increase 0.61 Decrease − 2.48
c.907C > T p.L303F Decrease − 1 Decrease − 1 Decrease 0.95
c.986C > T p.A329V Decrease − 0.34 Decrease − 0.88 Decrease 0.12
c.1070G > T p.R357L Increase 0.15 Increase 0.68 Increase 0.66
  1. CDS coding sequences, AA amino acid, SVM support vector machine, SVMCS SVM confidence score, NN neural network, NNCS neural network confidence score, DDG free energy change value