Fig. 5

Clustering of cancers and non-cancer diseases sharing daSNPs. In this network representation, red (resp. violet) nodes correspond to cancers (resp. non-cancer diseases) displaying TAD-border enrichment in daSNPs, orange (resp. light blue) nodes to other cancers (resp. other non-cancer diseases). An edge is drawn between two diseases when they share an associated SNP A located in a TAD border for a majority of values of the window parameter k (border SNPs, see Methods) or B belonging to the complementary set (non-border SNPs). C, D Same as (A, B) when considering only intergenic SNPs. The four networks have been visualized using NetworkX Python package. Underlying Hi-C data from [30], IMR90 cell type, 10 kb-resolution