Fig. 2
From: Immune dysregulation associated with co-occurring germline CBL and SH2B3 variants
Immunological characterization. A Percentage of viable (7AAD-/AnnV-), apoptotic (7AAD-/AnnV +) or necrotic (7AAD +) PBMC investigated on patients II.2, III.2 and III.3 after 24 h of PHA-stimulation (1ug/ml); B surviving fraction (%) of CD4 and CD8 cells with or without PHA-stimulation; C Modulation of pAKT expression by IC87114 inhibitor (5 mM, for 30’) performed graphed as ratio between expression of pAKT /expression of B-actin (WB)