Articles

Pharmacogenetics of lipid diseases

The genetic basis for most of the rare lipid monogenic disorders have been elucidated, but the challenge remains in determining the combination of genes that contribute to the genetic variability in lipid leve...

Authors: Jose M. Ordovas

Development of an integrated genome informatics, data management and workflow infrastructure: A toolbox for the study of complex disease genetics

The genetic dissection of complex disease remains a significant challenge. Sample-tracking and the recording, processing and storage of high-throughput laboratory data with public domain data, require integrat...

Authors: Oliver S. Burren, Barry C. Healy, Alex C. Lam, Helen Schuilenburg, Geoffrey E. Dolman, Vincent H. Everett, Davide Laneri, Sarah Nutland, Helen E. Rance, Felicity Payne, Deborah Smyth, Chris Lowe, Bryan J. Barratt, Rebecca C.J. Twells, Daniel B. Rainbow, Linda S. Wicker…

Robustness of the inference of human population structure: A comparison of X-chromosomal and autosomal microsatellites

In this paper, data on 20 X-chromosomal microsatellite polymorphisms from the HGDP-CEPH cell line panel are used to infer human population structure. Inferences from these data are compared to those obtained f...

Authors: Sohini Ramachandran, Noah A. Rosenberg, Lev A. Zhivotovsky and Marcus W. Feldman

Matt Ridley

Authors:

Update on human genome completion and annotations: Gene nomenclature

Why is agreeing on one particular name for each gene important? As one genome after another becomes sequenced, it is imperative to consider the complexity of genes, genetic architecture, gene expression, gene-...

Authors: Daniel W Nebert and Hester M Wain

A survey of current software for linkage analysis

There is now a wide choice of software available for linkage analysis. The most well known packages are briefly reviewed here. The package with the most extensive range of analyses is GENEHUNTER, but for many ...

Authors: Frank Dudbridge

Measuring and using admixture to study the genetics of complex diseases

Admixture is an important evolutionary force that can and should be used in efforts to apply genomic data and technology to the study of complex disease genetics. Admixture linkage disequilibrium (ALD) is crea...

Authors: Indrani Halder and Mark D Shriver

Genome-wide characterisation of the binding repertoire of small molecule drugs

Most, if not all, drugs interact with multiple proteins. One or more of these interactions are responsible for carrying out the primary therapeutic effects of the drug. Others are involved in the transport or ...

Authors: Lee Makowski and Diane J Rodi

Reconstructing the genomic architecture of mammalian ancestors using multispecies comparative maps

Rapidly developing comparative gene maps in selected mammal species are providing an opportunity to reconstruct the genomic architecture of mammalian ancestors and study rearrangements that transformed this an...

Authors: William J Murphy, Guillaume Bourque, Glenn Tesler, Pavel Pevzner and Stephen J O'Brien

Integration of association statistics over genomic regions using Bayesian adaptive regression splines

In the search for genetic determinants of complex disease, two approaches to association analysis are most often employed, testing single loci or testing a small group of loci jointly via haplotypes for their ...

Authors: Xiaohua Zhang, Kathryn Roeder, Garrick Wallstrom and Bernie Devlin

Gametic phase estimation over large genomic regions using an adaptive window approach

The authors present ELB, an easy to programme and computationally fast algorithm for inferring gametic phase in population samples of multilocus genotypes. Phase updates are made on the basis of a window of ne...

Authors: Laurent Excoffier, Guillaume Laval and David Balding

Editorial

Authors: Li Jin and David B Goldstein